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王玮文
健康与遗传心理学研究室, 研究员
电 话:  86-10-64864516
传 真:  86-10-64872070
通讯地址:  北京市朝阳区林萃路16号院北楼
邮政编码:  100101
电子邮件:  wangww@psych.ac.cn
课题组网站:  

简历:
教育和工作经历:
2017年 -       中科院心理所研究员
2005年-2016年 中科院心理所副研究员,硕士生导师/
        期间2010年2-10月 宾夕法尼亚大学费城儿童医院儿童研究中心访问学者
        期间2014年- 博士生导师
2000年-2004年 中科院心理研究所生物心理学专业,获博士学位
1998年-2004年 中科院心理所实习研究员、助理研究员
1994年-1997年 沈阳药科大学药物分析专业,获硕士学位
1990年-1994年 新疆医学院药学系,获学士学位;
研究领域:
应激及应激相关精神疾病,包括抑郁症、精神分裂症和创伤后应激障碍等的心理神经免疫学;应激相关精神疾病易感与耐受的心理神经基础。结合人类和实验动物研究,采用行为学、遗传学和表观遗传学、分子生物学和电生理等方法,研究应激,尤其是早期应激与遗传因素交互作用影响精神疾病相关情绪和认知功能障碍的心理神经免疫机理及防治新策略。
社会任职:

2005年-至 今   中国心理学会生理心理学专业委员会秘书(长)
2013年-2018年   中国心理卫生协会心身医学专业委员会委员
2015年-至 今   中国动物学会动物行为学分会理事会常务理事
2015年-2018年   中国生理学会应激生理学专业委员会委员
20172017年-2020年 中国神经科学学会应激神经生物学分会委员

获奖及荣誉:
代表论著:

1. Xu, H. #, Zhang, Y.#, Zhang, F., Yuan, S., Shao, F., & Wang, W.* (2016). Effects of Duloxetine Treatment on Cognitive Flexibility and BDNF Expression in the mPFC of Adult Male Mice Exposed to Social Stress during Adolescence. Frontiers in Molecular Neuroscience, 9, 95.
2.Zhang, F. #, Yuan, S. #, Shao, F., & Wang, W.W.* (2016). Adolescent social defeat induced alterations in social behavior and cognitive flexibility in adult mice: effects of developmental stage and social condition. Frontiers in Behavioral Neuroscience, 10, 149,1-11.
3. Zhang, Y. #, Shao, F. #, Wang, Q., Xie, X., Wang, W.W.* (2016). Neuroplastic correlates in the mPFC underlying the impairment of stress-coping ability and cognitive flexibility in adult rats exposed to chronic mild stress during adolescence. Neural Plasticity, 10. doi: 10.1155/2017/9382797
4. Li, M., Du, W., Shao, F. *, Wang, W.W.* (2016). Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence. Behav Brain Res, 313, 177-183. 
5. Mwanza, C., Chen, Z., Zhang, Q., Chen, S., Wang, W. W., & Deng, H.H.* (2016). Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. Journal of Chromatography B, 1028, 1-10. 
6. 张权,陈崝,王玮文,邓慧华.创伤后应激障碍患者的HPA轴功能变化的时间序列特征. 《心理科学进展》, 2016,24(4):536-546 
7. Tian Yu, Hang Xu, Weiwen Wang, Shifei Li, Zheng Chen, Huihua Deng*. Determination of endogenous corticosterone in rodent’s blood, brainand hair with LC–APCI–MS/MS. Journal of Chromatography B, 2015, 1002: 267–276 
8. Qiong Wang, Feng Shao*, Weiwen Wang*. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. Frontiers in Molecular Neuroscience. 20158491-9, 
9. Weiwen Wang, Huihua Deng, Li Wang*, Chengqi Cao,Hang Xu, Jianxin Zhang. Hair cortisone level is associated with PTSD’s dysphoric arousal symptoms in highly traumatized Chinese females. Journal of affective disorders, 2015, 182, 18-22 
10.Yan Jin, Bin Luo, Yan-Yan Su,Xin-Xing Wang, Liang Chen*, Ming, Wang, Wei-Wen*, Lin Chen*. Sodium salicylate suppresses GABAergic 1 inhibitory activity in neurons of rodent dorsal raphe nucleus. Plos one, 2015, 10(5): e0126956. 
11.Qiong Wang, Man Li, Wei Du, Feng Shao*, Weiwen Wang*. The different effects of maternal separation on spatial learning and reversal learning in rats. Behavioural Brain Research, 2015, 280: 16–23. 
12.Huanhuan Li, Wenjuan Lin, Junfa Li, Weiwen Wang. Altered Neurogranin Phosphorylation and Protein Levels are Associated with Anxiety- and Depression-Like Behaviors in Rats Following Forced Swim Stress. Journal of Behavioral and Brain Science. 2014, 4: 506-522
13.Li Wang, Chengqi Cao, Weiwen Wang*, Hang Xu, Jianxin Zhang, Huihua Deng, Xiangyang Zhang. Linking hair cortisol levels to phenotypic heterogeneity of posttraumatic stress symptomatology in highly traumatized Chinese females. Biological Psychiatry. 2015; 77 :e21–e22 
14.Shuang Shao, ManLi, WeiDu, FengShao, Weiwen Wang*. Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment. Brain research, 2014, 1589:105-11 
15.原三娜;罗晓敏;张帆;邵枫;王玮文*. 大鼠注意定势转移任务模型的深入研究:种系和检测程序的影响. 心理学报,20144612):1-9 
16.Xi-ting Guan, Feng Shao, Xi Xie, Lin Chen, Weiwen Wang*. Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: comparison to fluoxetine and imipramine. Pharmacology, Biochemistry and Behavior. 2014, 124:361-366 
17.Xiao-Min Luo, San-Na Yuan, Xi-Ting Guan, Xi Xie, Feng Shaoc, Wei-Wen Wang*. Juvenile stress affects anxiety-like behavior and limbic monoamines in adult rats. Physiology & Behavior 135 (2014) 7–16 
18. , , 王玮文*. 中枢肥大细胞在脑 功能和行为调节中的作用. 心理科学进展 2014,22(9): 1–11 
19.薛晓芳, 李曼,王玮文,邵枫.母婴分离的动物模型及其神经生物学机制. 心理科学进展, 2013, 21(6): 990-998. 
20.Xue X., Shao S.,Wang W. *, Shao F. Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats. Neuropsychobiology 2013;68:243-24 
21.Li, M., Shao, S., Shao, F., Wang, W.W. *. Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats. Brain Research, 20131518, 82-90 
22.Xue, X.F., Shao, S., Li, M., Shao, F., Wang, W.W. *. Maternal separaton induces alterations of serotonergic system in different aged rats. Brain Research Bulletin, 201395, 15-20. 
23.Feng Shao, Xiao Han, Shuang Shao, & Weiwen Wang*. Adolescent social isolation influcences cognitive function in adult rats. Neural Regeneration Research, 2013, 8(11), 1025-1030. 
24.原三娜,王琼,邵枫,王玮文*. CRF 受体对五羟色胺系统的调节作用及早期环境因素的影响. 心理科学进展. 3013,21(06),1-8. 
25.Pan, Yuqin,Lin, Wenjuan,Wang, Weiwen,Qi, Xiaoli,Wang, Donglin,Tang, Mingming The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats. Behavioural Brain Research, 2013,247: 232-240 
26.Xiao Han, Nanxin Li, Xiaofang Xue, Feng Shao, Weiwen Wang*. Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats. Brain Research, 2012, 1 4 4 7: 3 8 – 4 3 
27.王琼,罗晓敏,邵枫,王玮文*. 两种慢性应激诱导的抑郁模型大鼠前额叶认知功能的比较研究。 中国神经精神疾病杂志,2012388):449- 
28.Xiao Han, Weiwen Wang, Feng Shao and Nanxin Li. Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats. Brain Research, 2011(18): 175-181 
29.Kevin Snyder, Wei-Wen Wang*, Rebecca Han, Kile McFadden and Rita J. ValentinoCorticotropin-releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Cognitive Flexibility. Neuropsychopharmacology,2011, 1–11. Co-author 
30.管西婷,谢希,罗晓敏,邵枫,王玮文*.青少期社会隔离和不确定性应激对大鼠成年后情绪行为的不同影响。中国神经精神疾病杂志,2011,37(3):406-410 
31.Xiao Han, Weiwen Wang, Xiaofang Xue, Feng Shao, Nanxin Li. Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats. Brain Research Bulletin, Brain Research Bulletin.,2011: 173– 178 
32.Han, X., Li, N., Meng, Q., Shao F., Wang, W*. Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-α in Offspring.. Neuropsychobiology, 2011,64(1): 9-14 
33.Meng, Q., Li, N., Han, X., Shao, F., & Wang, W*. Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain. European Journal of Pharmacology, 2011, 650(1): 229-232 
34.LuoX, Shao, F.Guan, X., Xie X., Wang, WW*. Progress in the “brain-derived neurotrophic factor depression hypothesis”. Neural Regeneration Research, 2010,5(23): 1817-1824 
35.Shao, F., Han, X., Li, N., & Wang, W*. Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats.. European Journal of Pharmacology, 2010, 649(1-3), 202-205. 
36.Meng, Q., Li, N., Han, X., Shao, F., & Wang, W*. Peri-adolescence isolation rearing alters social behavior and nociception in rats. Neuroscience Letters, 2010, 480(1), 25-29. 
37.谢希,邵枫, 罗晓敏, 管西婷, 孟庆轩,王玮文*. 氟西汀和丙米嗪对应激诱导的青幼期大鼠抑郁样行为的不同影响. 中国神经精神疾病杂志. 2010, 36(1)14-18 
38.Feng Shao, Jian Jin, Qingxuan Meng, Mei Liu, Xi Xie, Wenjuan Lin, Weiwen Wang*. Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats. Physiology & behavior, 2009, 98251-257 
39.Qi, Xiaoli, Lin, Wenjuan, Wang, Donglin, Pan, Yuqin, Wang, Weiwen, Sun, Meng. A role for the extracellular signal-regulated kinase signal pathway in depressive-like behavior. BEHAVIOURAL BRAIN RESEARCH, 2009199(2), 203-209 
40.王玮文 邵枫 刘美 金简 林文娟.慢性应激损害大鼠信号逆反学习能力:一种新的T型水迷宫检测方法.中国神经精神疾病杂志. 2009, 15(1): 42-44
41.金简王玮文, 孟庆轩, 刘美, 邵枫.不同发育阶段社会隔离对成年大鼠潜伏抑制的影响. 北京大学学报(自然科学版), 2008, 4: 80-84 
42.王玮文, 谢希, 邵枫. 早发性抑郁及其神经基础. 心理科学进展, 2008,16(3):411-417 
43.王玮文,邵枫,刘美,孙萌,林文娟. 慢性应激对大鼠行为和免疫细胞HSP70表达的影响. 心理学报,2007,39(5):500~510
44.王玮文,邵枫,刘美,林文娟. 衰老、慢性应激与免疫细胞热休克蛋白70反应抑制. 中国行为医学科学, 2007, 10951-953 
45.王玮文,邵枫,刘美,林文娟. 早期应激对抑郁相关行为及神经内分泌反应的长期影响. 心理科学进展,2006,14(6):907-911
46.Lin Wenjuan, Wang Weiwen and Shao Feng. A New Animal Model of Emotional Stress: Behavioral, Neuroendocrinological and Immunological consequences. Chinese Science Bulletin2003, 489: 926-929 

参译著作:
詹姆斯.卡拉特著,苏彦捷等译。生物心理学(第十版)(第十章).人民邮电出版社,2011

专利:
王玮文;林文娟;邵枫;杨震.一种多水平客观测定动物学习能力的行为实验系统和方法. 中国, 2005 1 0086956.9(发明专利)
王玮文;林文娟;邵枫;杨震.一种动物学习能力的行为测试用的水迷宫.中国, 200520142005.4(实用新型

承担科研项目情况:

1.国家自然科学基金项目面上项目,“青少期早期社会应激对抑郁样行为和前额叶GABA能系统的影响及其关系研究”,2015.1-2018.12,负责
2.心理健康院重点实验室重点课题,“早年创伤诱导快感缺失样抑郁行为的奖赏环路机制”,2016/01-2018/12,合作人
3.心理健康院重点实验室重点课题,“创伤后应激障碍患者HPA轴功能变化的时间序列特征”,2014.1-2016.12,合作
4.中国科学院“十二五”重点部署项目《中国特定人群的心理与社会行为研究》子课题“ 创伤后应激障碍临床异质性的心理神经机制”, 2013.1-2016.12,主要成员
5.国家自然科学基金项目重大研究计划培育项目,“应激影响青少年情绪和认知发展的BDNF调控机制及早期干预研究”,2012.1-2014.12,负责
6.中国科学院仪器设备功能开发技术创新项目,“基于多导生理记录仪的小动物生理信号植入式遥测和刺激系统”,2013.1-2014.12,主要成员
7.“创新与适应能力的早期培养与心理疾患的早期识别与干预”子课题“心理疾患的早期识别”,院基础前沿专项项目, 2011.3-2013.12,主要成员
8.心理健康院重点实验室重点课题,“青少期应激诱导成年抑郁行为的BDNF表观遗传调控机制”,2012.1-2013.12,负责
9.中国科学院心理研究所发展基金项目"青幼期应激对成年大鼠抑郁行为和神经可塑性的影响",2009-9011,负责
10.中国科学院创新工程重要方向项目子课题“青春期精神分裂及抑郁样行为的分子生物学研究”,2007-2010,负责
11.中科院心理研究所心理与健康院重点实验室引导性课题“天敌应激接种对大鼠抗应激能力的影响及其神经内分泌基础”,2009.3-2011.3,负责
12.国家重点基础研究计划(973)项目“抑郁症和精神分裂症的基因与环境相互作用机理研究”子课题”疾病的脑高级功能障碍”,2007-2011,主要成员
13.国家自然科学基金项目:早期隔离应激诱导的拟精神分裂症颠倒学习障碍的神经生物学机制,2007-2009,合作
14.国家自然科学基金项目"热休克蛋白70在抗应激所致免疫细胞功能改变中的作用",2006-2008,负责