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王玮文
健康与遗传心理学研究室 研究员
电 话:  86-10-64864516
传 真:  86-10-64872070
通讯地址:  北京市朝阳区林萃路16号院北楼
邮政编码:  100101
电子邮件:  wangww@psych.ac.cn
课题组网站:  

简历:

2016- 中国科学院心理研究所 研究员
2005-2016 中国科学院心理研究所 副研究员,硕士生导师
     期间2010年02-10月 费城儿童医院儿童研究中心 访问学者
     期间2014年- 博士生导师
2000-2004 中国科学院心理研究所生物心理学专业,获博士学位
1998-2005 中国科学院心理研究所研究实习员、助理研究员
1994-1997 沈阳药科大学药物分析专业,获硕士学位
1990-1994 新疆医学院药学系,获学士学位

研究领域:

应激与精神疾病的心理神经免疫学。结合人类和实验动物研究,采用行为学、遗传学和表观遗传学、分子生物学、电生理和显微成像等方法,研究应激尤其是生命早期发展关键期应激对脑结构与功能发育的影响与后期精神疾病患病风险增加的关系及其心理神经机理,建立高风险个体早期识别和干预的行为学和生物学标记物。

社会任职:
学术任职:

2017年- 中国心理学会生理心理学专业委员会副主任委员

2017年- 中国神经科学学会应激神经生物学分会副主任委员

2013年- 中国心理卫生协会心身医学专业委员会委员

2015年- 中国动物学会动物行为学分会理事会常务理事

2015年- 中国生理学会应激生理学专业委员会委员

2018年- 中国生理学会中医药脑稳态专业委员会委员

Brain and behavior 副主编

Frontiers in Molecular Neuroscience 编审

OBM Neurobiology 编委

获奖及荣誉:
代表论著:

2013年-

1.Hang Xu, Jiesi Wang, Haiyang Jing, Bart Ellenbroek, Feng Shao, Weiwen Wang*. mPFC GABAergic transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress, Neuropharmacology, 2020, 108412, https://doi.org/10.1016/j.neuropharm.2020.108412.

2.HaoZhou, Jiesi Wang, Yu Zhang, Feng Shao* and Weiwen Wang*. The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation. Frontiers in Integrative Neuroscience. 2020, 14: 551676.

3.Qiong Wang, Yingjuan Liu, Jianxu Zhang* and Weiwen Wang*. Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice. Frontiers in Psychology. 2020, 10: 3028.

4.Yuanyuan Xin, Zhuxi Yao, Weiwen Wang, Yuejia Luo, Andr_e Aleman and Jianhui Wu. Recent life stress predicts blunted acute stress response and the role of executive control. STRESS. 2020, 23 (3): 359–367. doi.org/10.1080/10253890.2019.1687684.

5.Yu Zhang, Hang Xu, Jiesi Wang, Fengyan Ren,b, Feng Shao, Bart Ellenbroek, Wenjuan Lin, Weiwen Wang. (2019). Transient upregulation of immune activity induced by adolescent social stress is involved in cognitive de?cit in adult male mice and early intervention with minocycline. Behavioral Brain Research, 374, 112136, doi.org/10.1016/j.bbr.2019.112136

6.Yu Zhang, Hang Xu, Fan Zhang, Feng Shao, Bart Ellenbroek, Jiesi Wang, Weiwen Wang*. (2019). Deficiencies of microglia and TNF? in the mPFC-mediated cognitive inflexibility induced by social stress during adolescence. Brain, behavior and immunity, 79, 256-266.

7.Wang, W., Wang, L., Xu, H., Cao, C., Liu, P., Luo, S., . . . Zhang, X. (2019). Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake. J Affect Disord, 248, 52-58. doi: 10.1016/j.jad.2019.01.029

8.Man Li; Weiwen Wang#; Lan Sun; Wei Du; Hao Zhou; Feng Shao, (2019). Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation. Behavioural Pharmacology. 30(4):311–319

9.Xin, Y., Yao, Z., Wang, W., Luo, Y., Aleman, A., Wu, J. (2019). Recent life stress predicts blunted acute stress response and the role of executive control. Stress, 12:1-9. doi.org/10.1080/10253890.2019.1687684

10.Zheng Chen, Quan Zhang, Shenghuo Chen, Weiwen Wang, Guoxiong Liu, Huihua Deng. (2019). Determination, intercorrelation and intraindividual stability of five steroids in hair, saliva and urine among chinese college students. Steroids, 149, 108418

11.Li, M., Xu, H., & Wang, W. * (2018). An Improved Model of Physical and Emotional Social Defeat: Different Effects on Social Behavior and Body Weight of Adolescent Mice by Interaction With Social Support. Frontiers in Psychiatry, 9(688). doi: 10.3389/fpsyt.2018.00688

12.Hang Xu, Jiesi Wang, Ke Zhang, Mei Zhao, Bart Ellenbroek, Feng Shao*, Weiwen Wang*. Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice. Psychoneuroendocrinology, 2018, 88: 92-101.

13.Zhang, Q., Chen, Z., Chen, S., Yu, T., Wang, J., Wang, W., & Deng, H. (2018). Correlations of hair level with salivary level in cortisol and cortisone. Life Sci, 193, 57-63. doi: 10.1016/j.lfs.2017.11.037

14.Qiong Wang, Feng Shao and Weiwen Wang*. Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress. Neural Plasticity, 2018, doi.org/10.1155/2018/9870985

15.Sun, Lan, Min, Li, Li, Man, Shao, Feng, & Wang, Weiwen* (2018). Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model. BRAIN RESEARCH BULLETIN,142,304-312.

16.Bart A. Ellenbroek, Weiwen Wang. The Translational Umbrella - A Novel Approach to the Study of the Biological Basis of Mental Health. OBM Neurobiology, 2018; 2(1), doi:10.21926/obm.neurobiol.1801008

17.Lan Sun, Li Min, Hao Zhou, Man Li, Feng Shao*, Weiwen Wang*, Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats. Behav Brain Res, 2017, 333: p. 258-266.

18.Zhang, Y., Shao, F., Wang, Q., Xie, X., Wang, W.W. * (2017). Neuroplastic correlates in the mPFC underlying the impairment of stress-coping ability and cognitive flexibility in adult rats exposed to chronic mild stress during adolescence. Neural Plasticity, 10. doi: 10.1155/2017/9382797

19.Jenny Berrío, Weiwen Wang, Bart A. Ellenbroek. Perspectives on the Neurobiology of Antipsychotic Drugs in Psychiatric Disorders. OBM Neurobiology.2017,1(1): doi:10.21926/obm.neurobiol.1701001

20.徐 航,陈焕新,王玮文*. GABA 能系统在应激诱发的抑郁症中的作用.心理科学进展. 2017, 25(12): 2075–2081

21.张 瑜,林文娟,王玮文*. 中枢免疫失衡与认知功能障碍:聚焦TNF的作用.心理科学进展. 2017, 25(12): 2036–2042

22.王琼,王玮文*,李曼,杜伟,邵枫*.阻断内侧前额叶皮质TrkB受体对大鼠认知和海马BDNF表达的影响. 2016, 48(5): 509-517.

23.Xu, H. #, Zhang, Y. #, Zhang, F., Yuan, S., Shao, F., & Wang, W. * (2016). Effects of Duloxetine Treatment on Cognitive Flexibility and BDNF Expression in the mPFC of Adult Male Mice Exposed to Social Stress during Adolescence. Frontiers in Molecular Neuroscience, 9, 95.

24.Zhang, F.#, Yuan, S. #, Shao, F., & Wang, W.W. * (2016). Adolescent social defeat induced alterations in social behavior and cognitive flexibility in adult mice: effects of developmental stage and social condition. Frontiers in Behavioral Neuroscience, 10, 149,1-11.

25.Li, M., Du, W., Shao, F. *, Wang, W.W. * (2016). Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence. Behav Brain Res, 313, 177-183.

26.Mwanza, C., Chen, Z., Zhang, Q., Chen, S., Wang, W. W., & Deng, H.H. * (2016). Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. Journal of Chromatography B, 1028, 1-10.

27.张权,陈崝,王玮文,邓慧华.创伤后应激障碍患者的HPA轴功能变化的时间序列特征. 《心理科学进展》, 2016,24(4):536-546

28.Tian Yu, Hang Xu, Weiwen Wang, Shifei Li, Zheng Chen, Huihua Deng*. Determination of endogenous corticosterone in rodent’s blood, brainand hair with LC–APCI–MS/MS. Journal of Chromatography B, 2015, 1002: 267–276

29.Qiong Wang, Feng Shao*, Weiwen Wang*. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. Frontiers in Molecular Neuroscience. 2015,8:49:1-9

30.Weiwen Wang, Huihua Deng, Li Wang*, Chengqi Cao,Hang Xu, Jianxin Zhang. Hair cortisone level is associated with PTSD’s dysphoric arousal symptoms in highly traumatized Chinese females. Journal of affective disorders, 2015, 182, 18-22

31.Yan Jin, Bin Luo, Yan-Yan Su,Xin-Xing Wang, Liang Chen*, Ming, Wang, Wei-Wen*, Lin Chen*. Sodium salicylate suppresses GABAergic 1 inhibitory activity in neurons of rodent dorsal raphe nucleus. Plos one, 2015, 10(5): e0126956.

32.Qiong Wang, Man Li, Wei Du, Feng Shao*, Weiwen Wang*. The different effects of maternal separation on spatial learning and reversal learning in rats. Behavioural Brain Research, 2015, 280: 16–23.

33.Huanhuan Li, Wenjuan Lin, Junfa Li, Weiwen Wang. Altered Neurogranin Phosphorylation and Protein Levels are Associated with Anxiety- and Depression-Like Behaviors in Rats Following Forced Swim Stress. Journal of Behavioral and Brain Science. 2014, 4: 506-522

34.Li Wang, Chengqi Cao, Weiwen Wang*, Hang Xu, Jianxin Zhang, Huihua Deng, Xiangyang Zhang. Linking hair cortisol levels to phenotypic heterogeneity of posttraumatic stress symptomatology in highly traumatized Chinese females. Biological Psychiatry. 2015; 77 :e21–e22

35.Shuang Shao, ManLi, WeiDu, FengShao, Weiwen Wang*. Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment. Brain research, 2014, 1589:105-11

36.原三娜;罗晓敏;张帆;邵枫;王玮文*. 大鼠注意定势转移任务模型的深入研究:种系和检测程序的影响. 心理学报,2014,46(12):1-9

37.Xi-ting Guan, Feng Shao, Xi Xie, Lin Chen, Weiwen Wang*. Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: comparison to fluoxetine and imipramine. Pharmacology, Biochemistry and Behavior. 2014, 124:361-366

38.Xiao-Min Luo, San-Na Yuan, Xi-Ting Guan, Xi Xie, Feng Shaoc, Wei-Wen Wang*. Juvenile stress affects anxiety-like behavior and limbic monoamines in adult rats. Physiology & Behavior 135 (2014) 7–16

39.张 帆, 雍 武, 邵 枫, 王玮文*. 中枢肥大细胞在脑 功能和行为调节中的作用. 心理科学进展 2014,22(9): 1–11

40.薛晓芳, 李曼,王玮文,邵枫.母婴分离的动物模型及其神经生物学机制. 心理科学进展, 2013, 21(6): 990-998.

41.Xue X., Shao S.,Wang W. *, Shao F. Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats. Neuropsychobiology 2013;68:243-24

42..Li, M., Shao, S., Shao, F., Wang, W.W. *. Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats. Brain Research, 2013,1518, 82-90

43..Xue, X.F., Shao, S., Li, M., Shao, F., Wang, W.W.*. Maternal separaton induces alterations of serotonergic system in different aged rats. Brain Research Bulletin, 2013,95, 15-20.

44.Feng Shao, Xiao Han, Shuang Shao, & Weiwen Wang*. Adolescent social isolation influcences cognitive function in adult rats. Neural Regeneration Research, 2013, 8(11), 1025-1030.

45.原三娜,王琼,邵枫,王玮文*. CRF 受体对五羟色胺系统的调节作用及早期环境因素的影响. 心理科学进展. 3013,21(06),1-8.

46.Pan, Yuqin,Lin, Wenjuan,Wang,Weiwen,Qi, Xiaoli,Wang, Donglin,Tang, Mingming. The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats. Behavioural Brain Research, 2013,247: 232-240

 

参译/编著作:

1.詹姆斯.卡拉特著,苏彦捷等译,生物心理学 (第十版)(第十章).人民邮电出版社,2011.

2.王福顺等,情绪心理学(第四章情绪的生理机制)(全国高等学校五年制临床医学专业第九轮规划教材).人民卫生出版社,2018

 

专利:

1、中国科学院心理研究所(王玮文,张伟,王杰思,井海洋). 基于一种触屏操作箱内的视觉空间配对学习过程的数据提取和精细化分析软件 V1.0. 软件著作权登记证书. 2020SR1162221.

2、王玮文;林文娟;邵枫;杨震.一种多水平客观测定动物学习能力的行为实验系统和方法. 中国, 2005 1 0086956.9(发明专利)

3、王玮文;林文娟;邵枫;杨震.一种动物学习能力的行为测试用的水迷宫.中国, 200520142005.4(实用新型

 

更多成果信息请见:http://ir.psych.ac.cn/wangww@psych.ac.cn

承担科研项目情况:

1. 国家自然科学基金项目面上项目,“小胶质细胞在青少期创伤后不同情绪障碍发展风险中的异质性作用及其神经可塑性机制”(82071517),2021.1-2024.12,主持,在研

2. 国家重点研发计划政府间国际科技创新合作重点专项课题,“神经营养因子参与神经退行性疾病的环路及机制研究”(2017YFE0126500),2019.8-2022.7,课题负责,在研

3. 国家自然科学基金项目面上项目,“青少期应激诱发抑郁症认知功能障碍的中枢免疫机制及干预新策略”(31771217),2018.1-2021.12, 61万,主持,在研

4. 国家自然科学基金项目面上项目,“青少期早期社会应激对抑郁样行为和前额叶GABA能系统的影响及其关系研究”(81471122), 2015/01-2018/12, 70万,主持,已结题。

5. 中国科学院“十二五”重点部署项目,“中国特定人群的心理与社会行为研究”子课题“ 创伤后应激障碍临床异质性的心理神经机制”(KSZD-EW-Z-008),2013/01-2016/12,220万,参与,已结题。

6. 国家自然科学基金项目重大研究计划培育项目,“应激影响青少年情绪和认知发展的BDNF调控机制及早期干预研究”(91132728), 2012/01-2014/12, 65万,主持,已结题。

7. 中国科学院基础前沿专项项目,“创新与适应能力的早期培养与心理疾患的早期识别与干预”子课题“心理疾患的早期识别” (KSCX2-EW-J-8), 2011/03-2013/12, 120万,参与,已结题。

8. 国家重点基础研究计划(973)项目,,“抑郁症和精神分裂症的基因与环境相互作用机理研究”子课题”疾病的脑高级功能障碍”(2007CB512306),2007/08-2011/12,300万,参与,已结题。

9. 国家自然科学基金青年项目,"热休克蛋白70在抗应激所致免疫细胞功能改变中的作用"(30500158),2006/01-2008/12,25万,主持,已结题。

10. 心理健康院重点实验室重点课题,“早年创伤诱导快感缺失样抑郁行为的奖赏环路机制”,2016/01-2018/12,合作者

11. 中国科学院心理研究所自主部署科研项目“重性抑郁症的功能分型及神经基础研究”(Y5CX152008),2015.11-2017.11,主要成员

12. 心理健康院重点实验室重点课题,“创伤后应激障碍患者HPA轴功能变化的时间序列特征”,2014.1-2016.12,合作 者

13. 国家支撑计划项目课题“创伤性应激障碍综合诊断监测体系的建立”(2013BA108B02),2013-2015,390万,主要成员

14. 中国科学院仪器设备功能开发技术创新项目,“基于多导生理记录仪的小动物生理信号植入式遥测和刺激系统”,2013.1-2014.12,主要成员