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常素华
遗传与健康心理学研究室, 副研究员
电 话:  86-10-64851267
传 真:  86-10-64851267
通讯地址:  北京市朝阳区林萃路16号院中科院心理所
邮政编码:  100101
电子邮件:  changsh@psych.ac.cn
课题组网站:  

简历:

2007年毕业于中国科学院计算技术研究所/北京基因组研究所获硕士学位后,留在北京基因组所工作,并于2008年6月转入中国科学院心理研究所工作至今。期间,2012年获得行为遗传学专业博士学位,2014年5月到2015年5月院公派到北卡罗莱纳大学教堂山分校的遗传系和生物统计系访学,2014年底成为硕士研究生导师。

常素华博士的主要研究领域是精神疾病的遗传机制及其应用研究,侧重于遗传数据的统计遗传学分析、多维数据的生物信息学整合分析、数据库和软件平台的开发、以及基于遗传学数据的疾病风险评估模型的开发。迄今在Molecular Psychiatry、Biological Psychiatry、Nucleic Acids Research、Journal Psychiatry Research等国际主流学术期刊发表了25篇学术论文,其中13篇为第一/并列第一/并列通讯作者。

研究领域:

精神疾病的遗传机制及其应用研究:遗传数据的统计遗传学分析,多维数据的生物信息学整合分析,数据库和软件平台的开发,基于遗传学数据的疾病风险评估模型开发。

社会任职:
获奖及荣誉:
代表论著:

(# first author, * corresponding author) 
1. Yang, L.#, Chang, S.#, Lu, Q., Zhang, Y., Wu, Z., et al. (2017). “A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder.Molecular Psychiatry (in press). 
2. Wang, J.#, S. Qu, W. Wang, L. Guo, K. Zhang, S. Chang, S.* and Wang, J.* (2016). "A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex." J Psychiatr Res 82: 23-29. 
3. Chang, S.#, Fang, K.#, Zhang, K., and Wang, J.*, 'Network-Based Analysis of Schizophrenia Genome-Wide Association Data to Detect the Joint Functional Association Signals', PLoS One, 10 (2015), e0133404.
4. Chang, S.#, Wang, J.#, Zhang, K., and Wang, J.*, 'Pathway-Based Analysis for Genome-Wide Association Study Data of Bipolar Disorder Provides New Insights for Genetic Study', Protein Cell, 6 (2015), 912-5.
5. L. Zong, J. Guan, M. Ealy, Q. Zhang, D. Wang, H. Wang, Y. Zhao, Z. Shen, C. A. Campbell, F. Wang, J. Yang, W. Sun, L. Lan, D. Ding, L. Xie, Y. Qi, X. Lou, X. Huang, Q. Shi, Chang, S., W. Xiong, Z. Yin, N. Yu, H. Zhao, J. Wang, J. Wang, R. J. Salvi, C. Petit, R. J. Smith, and Q. Wang, 'Mutations in Apoptosis-Inducing Factor Cause X-Linked Recessive Auditory Neuropathy Spectrum Disorder', J Med Genet, 52 (2015), 523-31.
6. Li, Z.#, Chang, S.#, Zhang, L.#, Gao, L., Wang, J*. Molecular genetic studies of ADHD and its candidate genes: A review. Psychiatry Research. 2014, 219:10-24. 
7. Zhang, K.#, Chang, S.#, Guo, L., Wang, J*. I-GSEA4GWAS v2: a web server for functional analysis of SNPs in trait-associated pathways identified from genome-wide association study Protein & Cell, 2014
8. Guo, L.Y., Du, Y., Chang, S., Zhang, W.N., Wang, J*. (2014). Applying differentially expressed genes from rodent models of chronic stress to researches of stress-related disease: an online database. Psychosom Med, 76 (2014), 644-9.
9. Gao, L., Li, Z., Chang, S., & Wang, J*. (2014). Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis. PLoS One, 9(3), e90407. doi: 10.1371/journal.pone.0090407
10. Guo, L., Du, Y., Chang, S., Zhang, K., & Wang, J*. (2014). rSNPBase: a database for curated regulatory SNPs. Nucleic Acids Res, 42 (D1): D1033-D1039. doi: 10.1093/nar/gkt1167 
11. Chang, S.#, Gao, L.#, Li, Z.#, Zhang, W.#, Du, Y., & Wang, J*. BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder. Biol Psychiatry. 2013, doi: 10.1016/j.biopsych.2013.04.016 
12. Zhang, W., Chang, S., Guo, L., Zhang, K., & Wang, J*. (2013). The neural correlates of reward-related processing in major depressive disorder: a meta-analysis of functional magnetic resonance imaging studies. J Affect Disord. doi: 10.1016/j.jad.2013.06.039
13. Guo, L.#, Zhang, W.#, Chang, S.#, Zhang, L., Ott, J., & Wang, J*. MK4MDD: a multi-level knowledge base and analysis platform for major depressive disorder. PLoS One, 2012, 7(10), e46335. doi: 10.1371/journal.pone.0046335
14. Chang, S., Zhang, W., Gao, L., & Wang, J*. Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources. Protein Cell, 2012, 3(7), 526-534. doi: 10.1007/s13238-012-2931-7 
15. Zhang, L.#, Chang, S.#, Li, Z., Zhang, K., Du, Y., Ott, J., & Wang, J*. ADHDgene: a genetic database for attention deficit hyperactivity disorder. Nucleic Acids Res, 2012, 40(Database issue), D1003-1009. doi: 10.1093/nar/gkr992 
16. Zhang, K., Chang, S., Cui, S., Guo, L., Zhang, L., & Wang, J*. (2011). ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Res, 39(Web Server issue), W437-443. doi: 10.1093/nar/gkr391
17. Fang, K., Zhao, H., Sun, C., Lam, C. M., Chang, S., Zhang, K., . . . Wang, J*. (2011). Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction. BMC Syst Biol, 5, 83. doi: 10.1186/1752-0509-5-83
18. Zhang, J., Mamlouk, A. M., Martinetz, T., Chang, S., Wang, J., & Hilgenfeld, R*. (2011). PhyloMap: an algorithm for visualizing relationships of large sequence data sets and its application to the influenza A virus genome. BMC Bioinformatics, 12, 248. doi: 10.1186/1471-2105-12-248
19. Yan, H., Chang, S., Tian, Z., Zhang, L., Sun, Y., Li, Y., . . . Wang, Y.*. (2011). Novel AroA from Pseudomonas putida confers tobacco plant with high tolerance to glyphosate. PLoS One, 6(5), e19732. doi: 10.1371/journal.pone.0019732
20. Zhang, L., Chang, S., & Wang, J*. (2011). Synthetic biology: From the first synthetic cell to see its current situation and future development. Chinese Science Bulletin, 56(3), 229-237. doi: DOI 10.1007/s11434-010-4304-z
21. Zhang, L., Chang, S., & Wang, J*. (2010). How to make a minimal genome for synthetic minimal cell. Protein Cell, 1(5), 427-434. doi: DOI 10.1007/s13238-010-0064-4
22. Zhang, K., Cui, S., Chang, S., Zhang, L., & Wang, J*. (2010). i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. Nucleic Acids Res, 38(Web Server issue), W90-95. doi: 10.1093/nar/gkq324
23. Zhu, X. #, Chang, S.#, Fang, K., Cui, S., Liu, J., Wu, Z., . . . Wang, J. (2009). MyBASE: a database for genome polymorphism and gene function studies of Mycobacterium. BMC Microbiol, 9, 40. doi: 10.1186/1471-2180-9-40
24. He, X. #, Chang, S. #, Zhang, J. #, Zhao, Q. #, Xiang, H., Kusonmano, K., . . . Wang, J. (2008). MethyCancer: the database of human DNA methylation and cancer. Nucleic Acids Res, 36(Database issue), D836-841. doi: 10.1093/nar/gkm730 
25. Chang, S.#, Zhang, J. #, Liao, X. #, Zhu, X., Wang, D., Zhu, J., . . . Wang, J. (2007). Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research. Nucleic Acids Res, 35(Database issue), D376-380. doi: 10.1093/nar/gkl779

承担科研项目情况:

1.国家自然科学基金委青年基金,“精神分裂症相关遗传变异的调控网络构建与分析”,项目负责人
2.中国科学院心理健康重点实验室自主课题,注意力缺陷多动障碍候选基因优先级排序研究,项目负责人