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张向阳
健康与遗传心理学研究室 研究员
电 话:  86-10- 64879520
传 真:  
通讯地址:  北京市朝阳区林萃路16号院中国科学院心理研究所
邮政编码:  100101
电子邮件:  zhangxy@psych.ac.cn
课题组网站:  

简历:

学历教育:
19849月-19897月 安徽医科大学-临床医学专业-医学学士
19929月-19957月 北京大学精神卫生研究所-精神病学 硕士
19959-19987月 北京大学精神卫生研究所-精神病学博士
19998月-20007月 美国罗格斯大学分子和行为研究所 博士后
20008月-20037月 美国耶鲁大学医学院精神医学系 博士后

工作经历:
19898月-19948月 北京回龙观医院-临床心理科-住院医师
19959月-19998月 北京回龙观医院-临床心理科-主治医师(科副主任/科支部书记)
20038月-20067月 美国耶鲁大学医学院精神医学系 副研究科学家
20068月-20097月 美国贝勒医学院精神医学系   助理教授
20098-20147月 美国贝勒医学院精神医学系    副教授
20148-20182月 美国德州大学休斯顿医学院精神医学系   副教授/主诊医生
20183--至今   中国科学院心理所健康与遗传心理学研究室 研究员

研究领域:

临床心理治疗和咨询

精神疾病认知功能研究

精神医学大数据和精准医学研究;

吸烟与精神疾病的关系;

精神疾病与自由基代谢;

精神疾病的免疫功能;

精神疾病遗传学研究;

精神疾病的神经营养因子研究;

精神疾病神经电生理研究;

精神疾病的核磁共振研究;

精神疾病临床精神药理研究:临床疗效和三种主要药物副作用(迟发性运动障碍、糖尿病和肥胖)
社会任职:

两家杂志的主编: Journal of Schizophrenia Disorders and Therapy; Journal of Addiction and Prevention
六家杂志的编委:心理学报; Journal of Affective Disorder ; Psychiatry Research; Plos One; Revista Brasileira de Psiquiatria (Brazilian Journal of Psychiatry); Current Pharmaceutical Design
三家学会会员:美国神经科学学会(Society for Neuroscience, SfN); 国际神经精神药理协会(Collegium Internationale Neurop-Psychopharmaclogicum, CINP); 美国药物依赖研究学会(College on Problems of Drug Dependence, CPDD)
海外华人精神医学学会 (Oversea Chinese Psychiatric Association, OCPA) 主席

获奖及荣誉:

科学成果和论文奖

2008 北京市科技成果二等奖

2006 13届精神分裂症研讨会“资深科学家奖”;瑞士,达沃斯

2006 世界精神卫生协会(WPA)“青年精神学家奖”;土耳其,伊斯坦布尔

2005 美国神经精神药理学会和美国国家精神卫生研究院(ACNP/NIMH)青年研究者奖; 美国,夏威夷

2005 66届美国药物依赖学会“青年科学家旅行奖”; 美国,佛罗里达

2004 7届国际神经免疫学大会“青年研究者奖”;意大利,威尼司

2003 64届美国药物依赖学会“国立药物滥用研究院青年科学家奖 美国佛罗里达

2000 10届精神分裂症研讨会“青年科学家奖”;瑞士,达沃斯

1998 中华精神科学会“杨森文库”优秀论文一等奖;中国,北京

1996 北京市“科技新星计划”

1996 中华医学会和中华神经精神科学会“优秀论文”二等奖;中国,北京

1995 北京卫生局科技成果二等奖;

1993 北京卫生局科技成果二等奖;

1992 卫生部和中华医学会第7届中青年医师“优秀论文”二等奖

荣誉奖

2005 被收录“第5版世界医学和健康名人录”

2000 北京市政府授予“北京市劳动模范”;

1999 北京市政府授予“第13届五四青年”奖章;

1999 卫生部授予“十大杰出青年岗位能手”;

1996  被收录中国科学院科学出版社“中国优秀科技成果展”;

1995 北京市团委授予“青年岗位能手”

1994 北京市政府授予“北京市优秀青年知识分子”,享受政府特殊津贴
代表论著:

1. He SC, Zhang YY, Zhan JY, Wang C, Du XD, Yin GZ, Cao B, Ning YP, Soares JC, Zhang XY. Burnout and cognitive impairment: Associated with serum BDNF in a Chinese Han Population. Psychoneuroendocrinology 2017; 77:236-243

2.Chen DC, Yang KB, Nie Y, Wang N, Li YL, Xiu MH, He SC, Yang FD, Kosten TR, Soares JC, Zhang XY. Impaired glucose tolerance in first-episode drug-naïve patients with schizophrenia: relationships to clinical phenotypes and cognitive deficits. Psychological Medicine 2016; 46(15):3219-3230.

3. Xiu MH, Tian L, Chen S, Tan YL, Chen DC, Chen J. Chen N, Yang FD, Licinio J, Kosten TR. Soares JC, Zhang XY. Contribution of IL-10 and its -592 A/C polymorphism to cognitive functions in first-episode drug-naive schizophrenia. Brain Behavior and Immunity 2016;57:116-124

4. Zhang XY, Tan YL, Chen DC, Tan SP, Malouta M, Bernard JD, Combs JL, Bhatti S, Davis MC, Kosten TR, Soares JC.   Serum IL-18 level, clinical symptoms and IL-18- 607A/C polymorphism among chronic patients with schizophrenia in a Chinese Han population. Psychoneuroendocrinology 2016; 68: 140–147

5. Zhang XY, Chen DC, Tan YL, Tan SP, Luo X, Zuo L, Soares JC. BDNF polymorphisms are associated with cognitive performance in schizophrenia versus healthy controls. Journal of Clinical Psychiatry  2016; 77(8):e1011-e1018.

6. Zhang XY, Fan FMChen DC, Tan YL, Tan SP, Salas R, Kosten TR, Zunta-Soares G, Soares JC. Extensive white matter abnormalities and clinical symptoms in first episode and drug-naïve schizophrenia: a voxel-based diffusion tensor imaging study. Journal of Clinical Psychiatry 2016;77(2): 205–211

7. Zhang XY, Tan YL, Chen DC, Tan SP, Yang FD, Wu HE, Zunta-Soares GB, Kosten TR, Huang XF, Soares JC. Interaction of BDNF with cytokines in chronic schizophrenia. Brain, Behavior and Immunity 2016; 51: 169-175

8. Hui L, Han M, Huang XF, Ye MJ, Zhang X, He JC, Lv MH, Soares JC, Zhang XY. Association between DβH 5'-insertion/deletion polymorphism and cognition in patients with chronic schizophrenia. Journal of Clinical Psychiatry 2016; 77(3):379-385

9. Zhang XY, Chen DC, Tan YL, An HM, Zunta-Soares GB, Huang XF, Soares JC. Glucose disturbances in first-episode drug-naïve schizophrenia: relationship to psychopathology.Psychoneuroendocrinology 2015; 58:130-140

10. Zhang XY, Chen DC, Tan YL, Tan SP, Wang ZR, Yang FD, Okusage OO, Zunta-Soares GB, Soares JC. The interplay between BDNF and oxidative stress in chronic schizophrenia. Psychoneuroendocrinology 2015 Jan; 51:201-208.

11. Zhang XY, Chen da C, Xiu MH, Yang FD, Tan YL, Luo X, Zuo L, Kosten TA, Kosten TR. Cognitive function, plasma manganese superoxide dismutase (MnSOD) and MnSOD Ala-9Val polymorphism in patients with schizophrenia and normal controls. Schizophrenia Bulletin 2014; 40(3): 592-601

12.Zhang XY, Chen DC, Tan YL, Tan SP, Wang ZR, Yang FD, Xiu MH, Hui L, Lv MH, Zunta-Soares GB, Soares JC. Gender difference in association of cognition with BDNF in chronic schizophrenia. Psychoneuroendocrinology 2014; 48:136-146.

13. Zhang XY, Chen da C, Xiu MH, Haile CN, Luo X, Zuo L, Kosten TA, Kosten TR. Cigarette smoking, psychopathology, and cognitive function in first-episode drug naïve schizophrenia: a case-control study. Psychological Medicine 2013; 43(8):1651-1660.

14. Zhang XY, Tang W, Xiu MH, Chen DC, De Yang F, Tan YL, Wang ZR, Zhang F, Liu J, Liu L, Chen Y, Wen N, Kosten TR. Interleukin 18 and cognitive impairment in first episode and drug naïve schizophrenia versus healthy controls. Brain Behavior and Immunity 2013; 32:105-111. 

15. Zhang X, Hui L, Liu Y, Wang ZQ, You Y, Miao LN, Sun SL, Guan SL, Xiang Y, Kosten TR, Zhang XY. The type 2 diabetes mellitus susceptibility gene IGF2BP2 is associated with schizophrenia in a Han Chinese population. Journal of Clinical Psychiatry 2013; 74(4): 287-292.

16. Zhang R, Miao Q, Wang C, Zhao R, Li W, Haile CN, Nielsen DA, Hao W, Kosten TR, Zhang XY. Genome-wide DNA methylation analysis in alcohol dependence in a male Chinese population. Addictive Biology 2013; 18(2):392-403

17. Zhang XY, Liu L, Liu S, Hong X, Chen DC, Xiu MH, Kosten TA, Kosten TR. Short-term tropisetron treatment and cognitive and P50 auditory gating deficits in schizophrenia. American Journal of Psychiatry 2012; 169974-981

18. Zhang XY, Chen DC, Xiu MH, Haile CN, Zhang HP, Luo X, Xu K, Kosten TA, Kosten TR. Brain-derived neurotrophic factor levels and its Val66Met gene polymorphism predict tardive dyskinesia treatment response to Ginkgo biloba . Biological Psychiatry 2012; 72: 700-706

19. Zhang XY, Chen da C, Xiu MH, Yang FD, Haile CN, Kosten TA, Kosten TR. Gender differences in never-medicated first-episode schizophrenia and medicated chronic schizophrenia patients. Journal of Clinical Psychiatry 73(7):1025-1033 (2012).

20. Zhang XY, Chen DC, Xiu MH, Haile CN, Zhang HP, Luo X, Xu K, Kosten TA, Kosten TR. Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls. Human Genetics 131:1187-1195 (2012).

21. Zhang XY, Tan YL, Zhou DF, Haile CN, Wu GY, Cao LY, Kosten TA, Kosten TR. Nicotine dependence, symptoms and oxidative stress in male patients with schizophrenia. Neuropsychopharmacology 32:2020-2024 (2007).

22. Zhang XY, Tan YL, Zhou DF, Cao LY, Wu GY, Haile CN, Kosten TA, Kosten TR. Nicotine dependence, symptoms, and oxidative stress in male patients with schizophrenia. Neuropsychopharmacology 32 (9), 2020-2024, (2007)

23. Zhang XY, Kosten TA. Previous exposure to cocaine enhances cocaine self-administration in an alpha 1-adrenergic receptor dependent manner. Neuropsychopharmacology 32:638-645 (2007).

24. Zhang XY, Tan YL, Zhou DF, Cao LY, Wu GY, Haile CN, Kosten TA, Kosten TR. Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenic patients with tardive dyskinesia. Journal of Clinical Psychiatry 68:754-760 (2007).

25. Zhang XY, Kosten TA. Prazosin, an alpha-1 adrenergic antagonist, reduces cocaine-induced reinstatement of drug-seeking. Biological Psychiatry 57:1202-1024 (2005).

26. Zhang XY, Haile CN, Tan YL, Zuo LJ, Yang BZ, Cao LY, Zhou DF. Tumour necrosis factor alpha polymorphism (-1031T/C) is associated with age of onset of schizophrenia. Molecular Psychiatry 10:897-899 (2005).

27. Zhang XY, Zhou DF, Cao LY, Wu GY, Shen YC. Cortisol and cytokines in chronic and treatment-resistant patients with schizophrenia: association with psychopathology and response to antipsychotics. Neuropsychopharmacology 30:1532-1538 (2005).

说明:发表260多篇SCI论文,其中第一/通讯作者190多篇,30多篇影响因子IF>5分,6>10分。最近六年,每年发表SCI文章20多篇。文章总影响因子超过1000分,被引用6200多次。h-index= 44 (Google Scholar),发表的论文被《Faculty of 1000》(两次)、美国精神病学会(APA)的官方杂志《精神病学消息》、《国际神经病学和精神病学年鉴》和《精神卫生循证医学》等四家国际专业杂志进行收录和评论。另外发表中文论文100余篇。
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